"Homeostatic Imbalances". Anti Essays. 16 Dec. 2015

Medical Thermography (digital infrared thermal imaging - DITI ) is used as a method of research for early pre-clinical diagnosis and control during treatment of homeostatic imbalances. There are few devices, which operate in a passive method like infrared Thermography medicine; amongst these are the ECG and EEG. The intrinsic safety of this method makes infrared Thermography free from any limitations or contra- indications.

Indicators of cardiovascular homeostatic imbalance:

Homeostatic Imbalance-most disease is seen to be the result of

Cardiovascular disease is the consequence of a complex series of events that begins with one or more homeostatic imbalances initiated by abnormal gene environment interaction(s). Factors or agents that induce biochemical or physical stress/injury can elicit pathophysiological responses that include molecular, cellular, tissue, and/or integrative processes. Accordingly, the responses may be of a systemic, circulating, or local nature. In genetically susceptible individuals, these pathophysiologic responses can result in tissue damage, ultimately leading to impaired tissue function, target organ failure, clinical events, or death.

what is homeostatic imbalance, and what diseases result from it?

Current paradigms for diabetes treatment are inadequate at responding accurately to short term homeostatic imbalances and cannot prevent chronic diabetes-related complications. Predictably, novel approaches to re-establish homeostatic conditions in patients afflicted by type 1 diabetes (T1D) are now under intense investigation. Notably, the ex vivo generation and injection of tolerance-promoting dendritic cells (DCs) is being pursued in clinical trials for applications in T1D. While instructive, exogenously-conditioned cellular-based vaccines for T1D treatment have numerous limitations. Dissemination of exogenously delivered DCs is inefficient, and treatment involves a personalized medicine approach involving the generation of cultured DCs, which amounts to high production and treatment costs that prohibit widespread application. To circumvent these limitations, we are developing a multifunctional, synthetic microparticle-encapsulating vaccine that can be easily administered with simultaneous and continuous delivery using controlled-release materials (poly lactide-co-glycolide) for the in vivo conditioning of DCs and amelioration of T1D. Moreover, these microparticle-based vaccines are engineered to target DCs, and provide both intracellular and extracellular delivery of immunomodulatory agents as well as antigen. Our ultimate goal is to develop a microparticle-based (MP) vaccine capable of reversal of T1D in humans. To date, we have demonstrated (i) the ability of targeted MPs to improve in vivo DC uptake and translocation, (ii) the effect of our non-targeted MP vaccine on bone marrow-derived DC phenotype and downstream effects on allogeneic T cells, and (iii) the efficacy of the non-targeted MP vaccine to prevent diabetes onset in NOD mice. Current investigative work is focused on exposing the cellular mechanisms behind the observed prevention in NOD mice, reversal of type 1 diabetes and, evaluating the safety of this biomaterial formulation in rodent models (at OneVax, LLC), with an eye on full translation of this technology.

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homeostatic imbalance treatment

homeostatic imbalance treatment

Homeostatic imbalance occurs when the human body’s internal environmental variables become disturbed. The condition can be attributed to a number of factors which include the aging of the person’s organs and the organ’s control systems or feedback mechanisms, which can cause them to malfunction or not perform up to the standard that has been normal throughout the majority of the person’s lifetime. Homeostasis can also be disturbed when certain pathological situations are present in the body and overwhelm the controls and mechanisms that have been behaving in a healthy and life-sustaining manner. The stability of the homeostatic mechanism is achieved, for the most part, by a series of mechanisms that balance the input and output of signals, chemicals, and fluids. Most diseases can be at least partly attributed to the presence of homeostatic imbalance within the system.

is graves disease homeostatic imbalanceVisitor #

is graves disease homeostatic imbalance

Metabolomics is an emerging technology that reveals homeostatic imbalances in biological systems. Global determination of concentrations in body fluid and tissues provides novel anatomical aspects of pathological conditions that cannot be obtained from target-specific measurements. Here, we characterised metabolic imbalance in Watanabe heritable hyperlipidaemic rabbits as a model of hypercholesterolaemia. Using a mass spectrometry-based system, we measured a total of 335 in plasma and tissues (liver, aorta, cardiac muscle, and brain) from WHHL and healthy control rabbits. From the comparison between two metabolomic profiles, pathophysiological features including and metabolism indicated the occurrence of oxidative stress in several tissues. Especially for the liver, imbalanced catabolism shed light on the transcriptional activation of oxidase, which is thought to act in absorbing or possibly triggering oxidative stress. We also applied this system to assess the therapeutic effects of simvastatin administration. After the treatment, a portion of the metabolomic features in pathological conditions showed alterations suggesting restoration of metabolism to the healthy condition. These changes were considered to be due to the pleiotropic action of statin, including effects, rather than its main inhibitory action on biosynthesis.

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homeostatic imbalance of the parietal lobe

The inefficiencies in homeostatic balance caused by the aging process are the main culprit in normal signs of aging like the breakdown of skin, the dulling of mental processes, and the decreased ability of the person to perform physical activity. In addition, the inevitable increases in homeostatic imbalance lead to many of the serious diseases associated with the aging population like diabetes, , and . In the example of heart failure, the negative feedback systems associated with heart and circulatory function are overwhelmed and destructive positive feedback mechanisms take over, contributing to the serious and sometimes fatal nature of the condition. Homeostatic control mechanisms control the imbalance of toxins in the bloodstream as well. When increased amounts of substances are introduced into the system and homeostatic imbalance is present, as in the example of gout, a buildup of toxic uric acid is the primary cause of the painful and chronic symptoms of the disease.